Selenium is a cofactor of that release active in cells and therefore low levels can cause similar signs and symptoms as iodine deficiency. The other important function of selenium is as an .
Selenium Functions and Health Benefits
Around twenty-five known proteins require selenium to function. Some are enzymes involved in detoxifying and include glutathione peroxidases and thioredoxin reductase. As an integral functioning part of these enzymes, selenium aids in the regeneration of glutathione and oxidized vitamin C. Selenium as part of also protects lipids from free radicals, and, in doing so, spares . This is just one example of how antioxidants work together to protect the body against free-radical induced damage. Other functions of selenium-containing proteins include protecting endothelial cells that line tissues, converting the inactive thyroid hormone to the active form in cells, and mediating inflammatory and immune system responses.
Observational studies have demonstrated that selenium deficiency is linked to an increased risk of cancer. A review of forty-nine observational studies published in the May 2011 issue of the Cochrane Database of Systematic Reviews concluded that higher selenium exposure reduces overall cancer incidence by about 34 percent in men and 10 percent in women, but notes these studies had several limitations, including data quality, bias, and large differences among different studies. Additionally, this review states that there is no convincing evidence from six clinical trials that selenium supplements reduce cancer risk.
Because of its role as a lipid protector, selenium has been suspected to prevent cardiovascular disease. In some observational studies, low levels of selenium are associated with a decreased risk of cardiovascular disease. However, other studies have not always confirmed this association and clinical trials are lacking.
Figure 11.4 Selenium’s Role in Detoxifying Free Radicals
Dietary Reference Intakes for Selenium
The IOM has set the RDAs for selenium based on the amount required to maximize the activity of glutathione peroxidases found in blood plasma. The RDAs for different age groups are listed in Table 11.6 “Dietary Reference Intakes for Selenium”.
Table 11.6 Dietary Reference Intakes for Selenium
|Age Group||RDA Males and Females mcg/day||UL|
|Infants (0–6 months)||15*||45|
|Infants (7–12 months)||20*||65|
|Children (1–3 years)||20||90|
|Children (4–8 years)||30||150|
|Children (9–13 years)||40||280|
|Adolescents (14–18 years)||55||400|
|Adults (> 19 years)||55||400|
|*denotes Adequate Intake|
Selenium at doses several thousand times the RDA can cause acute toxicity, and when ingested in gram quantities can be fatal. Chronic exposure to foods grown in soils containing high levels of selenium (significantly above the UL) can cause brittle hair and nails, gastrointestinal discomfort, skin rashes, halitosis, fatigue, and irritability. The IOM has set the UL for selenium for adults at 400 micrograms per day.
Dietary Sources of Selenium
Organ meats, muscle meats, and seafood have the highest selenium content. Plants do not require selenium, so the selenium content in fruits and vegetables is usually low. Animals fed grains from selenium-rich soils do contain some selenium. Grains and some nuts contain selenium when grown in selenium-containing soils. See Table 11.7 “Selenium Contents of Various Foods” for the selenium content of various foods.
Table 11.7 Selenium Contents of Various Foods
|Food||Serving||Selenium (mcg)||Percent Daily Value|
|Brazil nuts||1 oz.||544||777|
|Crab meat||3 oz.||41||59|
|Ricotta cheese||1 c.||41||59|
|Ground beef||3 oz.||18||26|
|Round steak||3 oz.||28.5||41|
|Beef liver||3 oz.||28||40|
|Whole-wheat bread||2 slices||23||33|
|Barley, cooked||1 c.||13.5||19|
|Milk, low-fat||1 c.||8||11|
|Walnuts, black||1 oz.||5||7|
Source: US Department of Agriculture, Agricultural Research Service. 2010. USDA National Nutrient Database for Standard Reference, Release 23. http://www.ars.usda.gov/ba/bhnrc/ndl.
Technology Note: The second edition of the Human Nutrition Open Educational Resource (OER) textbook features interactive learning activities. These activities are available in the web-based textbook and not available in the downloadable versions (EPUB, Digital PDF, Print_PDF, or Open Document).
Learning activities may be used across various mobile devices, however, for the best user experience it is strongly recommended that users complete these activities using a desktop or laptop computer and in Google Chrome.
- Dennert G, Zwahlen M, et al. (2011). Selenium for Preventing Cancer. Cochrane Database of Systematic Reviews,5. http://www.ncbi.nlm.nih.gov/pubmed/21563143. Accessed November 22, 2017. ↵
A protein molecule that speeds up or accelerates specific chemical reactions without changing itself.
Hormones that are produced by the thyroid gland and regulate metabolic rate.
Compounds that inhibit the oxidation of other substances.
A highly reactive atom or molecule that causes oxidative damage.
An enzyme containing selenium that protects cells from oxidative damage.
A fat-soluble vitamin that functions as an antioxidant in the body.